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J Biol Chem 1993, 268:1918819191

Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N

Prevalence and progression of NPS in AD patients Apathy, depression, anxiety, and agitation/aggression manifest early in AD, while hallucination and delusion generally occur at a later stage, often worsening as the disease progresses